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74th Scientific Sessions of the American Heart Association (AHA), November 2001, Anaheim, California
- Improved outcome of diabetic patients following coronary interventions with adjuvant brachytherapy: results from a large European, radiation therapy registry (RENO)
- Christoph K Naber, University of Essen, Essen Germany; Sigmund Silber, Klinik Dr. Mueller, Munich, Munich Germany; Thomas M Schiele, Klinikum Innenstadt, Munich, Munich Germany; Wolfgang Auch-Schwelk, University of Frankfurt, Frankfurt Germany; Phillip Urban, Centre Hospitalier Universitaire Vaudois, Lausanne, Lausanne Switzerland; Dietrich Baumgart, University of Essen, Essen Germany
- Circulation, 104, II-389 (2001)
Introduction : Intracoronary brachytherapy has proven to dramatically reduce the incidence of restenosis after percutaneous coronary interventions. This high efficacy for the prevention of restenosis remains to be proven within high risk populations such as type II diabetics.
Methods: From 1124 patients included in 43 European centers 262 were diabetics. All patients underwent intracoronary irradiation utilizing the Novoste Beta-Cath™ system consisting of a Sr/Y90-source train of 30, 40 or 60mm length, respectively.
Results: The technical success rate was >95%, mean dwell time was 3.3±0.5 min in diabetics and 3.4±0.5 min in non diabetic patients. Vessel diameter and lesion length were similar in both populations (3.2±0.1 vs 3.2±0.5 mm and 18.9±11.5 vs. 19.3±12.2 mm). Diabetic patients were slightly older and included more women and individuals with unstable angina. Current 6-month follow up includes 164 diabetic and 554 non-diabetic patients. Overall MACE rate (17.7 vs. 18.1%;n.s.), angiographic restenosis (20.2 vs. 20.2%;n.s.), and target vessel revascularization (15.2 vs. 15.9%) were comparable in both groups.
Conclusions: In comparison with previous trials, diabetic patients demonstrated an improved outcome after additional intracoronary irradiation, which was comparable with non-diabetic patients.
